Generally speaking, we recommend that you take your dentures out when you go to bed. Wearing your prosthetic during the day puts a lot of pressure on your gums, and if you don’t give them time to rest, you’re likely to see an uptick in the number of sore spots and the amount of irritation that you have to deal with.
Moreover, this is a good opportunity to leave your dentures to soak in a disinfectant solution, ensuring that they’re nice and clean as soon as you wake up. You aren’t going to be using your dentures while you sleep anyway, so why not let your gums have a break?